KABC Saturday, December 24, 2016 11:21PM LAGUNA WOODS, Calif. (KABC) — Authorities are seeking the public’s help locating a missing man with memory loss and medication needs in the Laguna Woods area. Joseph Samperi, 67, was last seen in the 3000 block of Via Vista in Laguna Woods around 10 a.m. Saturday. Samperi had a recent brain injury, causing memory loss, officials said. He has no personal identification other than a medical alert necklace. He is in need of blood pressure medication. Family members say Samperi lives in Pomona, but was visiting a relative in Laguna Woods and wandered away unnoticed from a medical transport vehicle. OCSDPIO At risk missing: Joseph Samperi, 67yrs, area of Laguna Woods, on foot, needs medical care, has no ID, wearing jeans, sweatshirt. pic.twitter.com/GCafjCuwEh OC Sheriff, CA (@OCSD) December 25, 2016 He was believed to be wearing blue jeans, a gray long-sleeve shirt and a dark-colored hooded sweatshirt.

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“And that really is crossing what people refer to all of the time as the ‘Valley of Death,’ where good research discoveries have a hard time moving into the clinical testing phase due to lack of funding,” he said. “Importantly, at this early stage, the FDA has only granted permission to assess potential safety of this investigational new drug in healthy volunteers” said Conn. “We cannot predict the outcome, but if these studies are successful in demonstrating that the investigational drug can be safely administered to humans, this would pave the way to allow filing of additional applications with the FDA to seek permission to advance to testing for efficacy in improving cognitive function in patients suffering from Alzheimer’s disease, and possibly schizophrenia or other brain disorders. While we cannot predict the outcome of any future safety or efficacy studies, this decision by FDA allowing clinical research to begin represents a major milestone in allowing us to hopefully provide answers to those critical questions in the future.” VCNDD Co-Director Craig W. Lindsley, Ph.D., director of Medicinal Chemistry and William K. Warren, Jr. Professor of Medicine, said Phase I testing will assess drug safety and tolerability in healthy volunteer participants, a process that could take a year. If successful, the Phase II and III studies would include efficacy assessments in patients with Alzheimer’s disease and could take three to five years to complete. “We are hoping to address what we see as an unmet medical need,” Lindsley said. “For Alzheimer’s patients, the standard of care for symptomatic treatment remains cholinesterase inhibitors, which are 25 years old at this point.

For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/vumc-ind122716.php

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